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KMID : 0363320000210010108
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Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 1 p.108 ~ p.115
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Influence of Gami-oryungsan on bromobenzene-induced liver injury in experimental animal
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Kim Jong-Dae
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Abstract
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Objective : To investigate the hepatoprotective effects of Gami-oryungsan on the liver damage induced by bromobenzene.
Method : The development of fibrosis and acute liver injury was examined by the chemical analysis of AST, AL T, -GTP . and epoxide hydrolase glutathione S-transferase glutathione peroxidase enzyme activity, lipidoperoxide levels, glutathione levels were measured and oberved.
Results : The increasing levels of lipidoperoxide was decreased proportionally according to dose of extract GO. Epoxide hydrolase glutathioneS-transferase glutathione peroxidase enzyme activity highly increased in GO pre-acupunctured group compared with the group treated with only bromobenzene. The increase of serum AST, AL T, -GTP enzyme activity of mice by bromobenzene was inhibited by the administration of GO. Lipidoperoxide levels in rat’s liver decreased compared to the case of bromobenzene-treated group. The levels of Glutathione decreased by bromo benzene were increased highly in GO pre-acupunctured group.
Conclusion : These results suggest that GO extract recovers the damage of liver due to bromobenzene intoxication by decreasing the lipid peroxidation AST AL T -GTP enzyme activity and increasing epoxide hydrolase glutathioneS-transferase glutathione peroxidase enzyme activity, glutathione levels.
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KEYWORD
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AST, ALT, -GT, epoxide hydrolase, glutathione
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